Author(s): Nordon C, Rouillon F, Barry C, Gasquet I, Falissard B
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Abstract BACKGROUND: Knowing the determinants of treatment satisfaction can provide better understanding of patient expectations in schizophrenia. The aim of this study was to determine which treatment-related factors were associated with treatment satisfaction, independently of patient-related or illness-related factors, in schizophrenia patients. METHODS: A cross-sectional study of data collected nationwide in France between 2005 and 2006 was conducted. 5500 adult patients with non-acute schizophrenia and requiring a switch of antipsychotic drug were included by 995 psychiatrists. Treatment satisfaction was assessed using the "PAtient SAtisfaction with Psychotropics" (PASAP) self-report questionnaire. Linear mixed model was used to explore the association between treatment satisfaction and treatment-related factors-including the current antipsychotic drug (none, first or second-generation antipsychotic) and psychosocial therapy-independently of patient-related and illness-related factors. FINDINGS: 3630 (66\%) patients filled in the PASAP questionnaire. Main treatment-related determinants of higher levels of satisfaction were: (1) being on second-generation antipsychotics compared to first-generation antipsychotics (olanzapine: ß=1.2; CI95\%=[0.5; 2.0], risperidone: ß=0.9; CI95\%=[0.1; 1.6], clozapine: ß=2.5; CI95\%=[0.6; 4.3] and amisulpride: ß=1.2; CI95\%=[0.3; 2.1]) and (2) participating in psychosocial therapy (ß=0.9; CI95\%=[0.3; 1.5]). CONCLUSION: Treatment satisfaction in non-acute schizophrenia was related to the more recent antipsychotic agents and psychosocial therapy, which may reflect expectations of more pro-active care. Copyright © 2012 Elsevier B.V. All rights reserved.
This article was published in Schizophr Res
and referenced in Journal of Psychiatry