Author(s): Posac JR, Vzquez MD, Tascn ML, Acua JA, de la Fuente C,
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Abstract An electroanalytical method for determination of the anti-inflammatory agent aceclofenac at the ppb level using adsorptive stripping voltammetric techniques on conventional and surfactant chemically modified electrodes is developed. In this electroanalytical study a process of aceclofenac adsorption on carbon particles has been identified. In order to improve the aceclofenac determination, a chemical modification of the carbon paste was carried out employing several hydrophobic substances such as phospholipid and fatty acids, as well as several surfactants such as the non-ionic Triton X-100 and Triton X-405 and anionic sodium dodecyl sulfate. The influence of parameters such as pH, preconcentration time, carbon Nujol ratio, surfactant carbon ratio, potential scan rate, etc., on sensitivity of the method were widely studied. The proposed method was applied to the determination of the active compound in tablets.
This article was published in Talanta
and referenced in Bioenergetics: Open Access