alexa Determination of bromhexine and ambroxol in pharmaceutical dosage forms, urine and blood serum.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): PrezRuiz T, MartnezLozano C, Sanz A, Bravo E

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Abstract Data presented in this paper show that bromhexine and its pharmacologically active metabolite can easily be determined by capillary zone electrophoresis. The composition of the running buffer had a significant effect on the reproducibility of the migration time for which a carrier solution containing 30 mM phosphate buffer (pH 3.0), 5 M urea and 10\% (v/v) acetonitrile was used. The method was validated with respect to its response linearity and reproducibility. The method is suitable for the determination of bromhexine and ambroxol in several samples such as pharmaceuticals, urine and serum. Photodiode-array detection permitted the rapid identification of both drugs in the sample analyzed.
This article was published in J Chromatogr B Biomed Sci Appl and referenced in Pharmaceutica Analytica Acta

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