alexa Determination of clarithromycin in human plasma by HPLC with electrochemical detection: validation and application in pharmacokinetic study.
Chemical Engineering

Chemical Engineering

Journal of Chromatography & Separation Techniques

Author(s): Niopas I, Daftsios AC

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Abstract A rapid, specific, precise and accurate HPLC method with electrochemical detection was developed and validated for the determination of clarithromycin in human plasma. After addition of the internal standard, the analytes were extracted from plasma under alkaline conditions with ethyl acetate:hexane 1:1. The inter-run precision of the method was less than 4.7\%, the inter-run accuracy was better than 97.3\% and the recovery of clarithromycin and roxithromycin (internal standard) were better than 82.5\% and 86.2\%, respectively. The method was found to be suitable for the quantitation of clarithromycin in bioequivalence and pharmacokinetic studies. Copyright 2001 John Wiley & Sons, Ltd. This article was published in Biomed Chromatogr and referenced in Journal of Chromatography & Separation Techniques

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