alexa Determination of diclofenac sodium by capillary zone electrophoresis with electrochemical detection.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Ji W, Zhan J

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Abstract Capillary zone electrophoresis was employed for the determination of diclofenac sodium using an end-column amperometric detection with a carbon fiber microelectrode, at a constant potential of 0.83 V vs. saturated calomel electrode. The optimum conditions of separation and detection are 4.90 x 10(-3) mol/l Na2HPO4-3.10 x 10(-3) mol/l NaH2PO4 (pH 7.0) for the buffer solution, 10 kV for the separation voltage, 5 kV and 10 s for the injection voltage and the injection time, respectively. The limit of detection is 2.5 x 10(-6) mol/l or 5.2 fmol (S/N=2). The relative standard deviation is 0.8\% for the migration time and 4.7\% for the electrophoretic peak current. The method was applied to the determination of diclofenac sodium in human urine.
This article was published in J Chromatogr A and referenced in Pharmaceutica Analytica Acta

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