alexa Determination of fenoterol and salbutamol in pharmaceutical formulations by electrogenerated chemiluminescence.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Lindino CA, Bulhes LO

Abstract Share this page

Abstract Fenoterol and salbutamol were determined by electrogenerated chemiluminescence (ECL) coupled with flow injection analysis (FIA), using Ru(bpy)(3)(2+) as the luminescent substance. Fenoterol and salbutamol oxidize together with the ruthenium 2,2-bipyridyl at a platinum electrode, which leads to an increase in the luminescent intensity, and this increase is proportional to the analyte concentration. For fenoterol a linear calibration curve within the range from 1.0x10(-5) to 1.0x10(-4)mol l(-1) was obtained with a correlation coefficient of 0.998 (n=5) and for salbutamol the linear analytical curve was also obtained in this range with a correlation coefficient of 0.995 (n=5). The relative standard deviation was estimated as < or =2.5\% for 3x10(-5)mol l(-1) for fenoterol solution and as < or =1.3\% for 5.0x10(-5)mol l(-1) salbutamol solution for 15 successive injections. The limit of detection for fenoterol was 2.4x10(-7)mol l(-1) and for salbutamol was 4.0x10(-7)mol l(-1). Fenoterol and salbutamol were successfully determined in drug tablets and the soluble components of the matrix did not interfere in the luminescent emission. The results obtained using the luminescent methodology were not statistically different from those obtained by UV-spectrophotometry at 95\% confidence level. This article was published in Talanta and referenced in Pharmaceutica Analytica Acta

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version