alexa Determination of glycosylation sites and site-specific heterogeneity in glycoproteins.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Clinical & Experimental Pharmacology

Author(s): An HJ, Froehlich JW, Lebrilla CB

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Abstract Glycosylation is one of the most common post-translational modifications (PTMs) of proteins. At least 50\% of human proteins are glycosylated with some estimates being as high as 70\%. Glycoprotein analysis requires determining both the sites of glycosylation as well as the glycan structures associated with each site. Recent advances have led to the development of new analytical methods that employ mass spectrometry extensively making it possible to obtain the glycosylation site and the site microheterogeneity. These tools will be important for the eventual development of glycoproteomics.
This article was published in Curr Opin Chem Biol and referenced in Journal of Clinical & Experimental Pharmacology

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