alexa Determination of octanol-water partition coefficients of pesticides by microemulsion electrokinetic chromatography.
Toxicology

Toxicology

Journal of Clinical Toxicology

Author(s): Klotz WL, Schure MR, Foley JP

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Abstract Microemulsion electrokinetic chromatography (MEEKC) was evaluated as a screening tool for the indirect measurement of octanol-water partition coefficients (log Po/w) of pesticide compounds. Over 80 pesticide compounds representing a variety of structural characteristics were studied, and good correlation of log Po/w with the logarithm of the retention factor was found. The microemulsion system studied allowed the separation of compounds in the log Po/w range of -1 to 7. In addition, a smaller set of simple organic molecules that vary in structural features was evaluated and compared to the pesticide log Po/w calibration. The pesticide and simple organic molecule log Po/w calibration lines were statistically similar. This suggests that a universal set of standard compounds may be employed for the log Po/w calibration to provide measurements for a variety of compounds with good accuracy.
This article was published in J Chromatogr A and referenced in Journal of Clinical Toxicology

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