alexa Determination of omeprazole in bulk and injectable preparations by liquid chromatography.
Chemical Engineering

Chemical Engineering

Journal of Chromatography & Separation Techniques

Author(s): Schubert A, Werle AL, Schmidt CA, Codevilla C, Bajerski L,

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Abstract An accurate, simple, reproducible, and sensitive liquid chromatographic method was developed and validated for the determination of omeprazole in powder for injection and in pellets. The analyses were performed at room temperature on a reversed-phase C18 column of 250 x 4.6 mm id, 5 microm particle size. The mobile phase, composed of methanol-water (90 + 10, v/v), was pumped at a constant flow rate of 1.5 mL/min. Detection was performed on a UV detector at 301 nm. The method was validated in terms of linearity, precision, accuracy, and ruggedness. The response was linear in the range 32-48 microg/mL (r2 = 0.9976). The relative standard deviation values for intra- and interday precision studies were 1.22 and 1.56\% for injectable and 2.13 and 2.45\% for pellets, respectively. Recoveries ranged between 95.81 and 100.48\%.
This article was published in J AOAC Int and referenced in Journal of Chromatography & Separation Techniques

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