alexa Development and Validation of a Stability-Indicating LC Method for Simultaneous Analysis of Aceclofenac and Paracetamol in Conventional Tablets and in Microsphere Formulations
Chemical Engineering

Chemical Engineering

Journal of Chromatography & Separation Techniques

Author(s): Shahid Jamil, Sushma Talegaonkar, Roop K Khar, Kanchan Kohli

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A stability-indicating reversed-phase LC method for analysis of aceclofenac and paracetamol in tablets and in microsphere formulations has been developed and validated. The mobile phase was 80:20 (v/v) methanol–phosphate buffer (10 mM at pH 2.5 ± 0.02). UV detection was at 276 nm. The method was linear over the concentration ranges 16–24 and 80–120 μg mL−1 for aceclofenac and paracetamol, respectively, with recovery in the range 100.9–102.22%. The limits of detection and quantitation for ACF were 0.0369 and 0.1120 μg mL−1, respectively; those for PCM were 0.0631 and 0.1911 μg mL−1, respectively. Keywords

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This article was published in Chromatographia and referenced in Journal of Chromatography & Separation Techniques

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