alexa Development and Validation of RP-HPLC method for th e Simultaneous estimation of Ciprofloxacin Hydrochlor ide and Ornidazole in Combined Pharmaceutical Dosage Form
Chemistry

Chemistry

Pharmaceutical Analytical Chemistry

Author(s): Ramya Krishna J, Naga B

Abstract Share this page

A simple, specific, accurate and precise reverse ph ase high performance liquid chromatographic method has been developed for the s imultaneous estimation of Ciprofloxacin hydrochloride and Ornidazole in pure and combined pharmaceutical dosage form. The quantification of the drug was carried ou t using Reverse phase phenomenex® Luna 5μ C18 (2) 100A (250 × 4.60 mm i.d) column in isocratic mode with mobile phase containing Acetonitrile and Water (p H adjusted to 2.5 with O-phosphoric acid) in the rat io of (75:25 % v/v) was used. The flow rate was 1ml/min a nd the effluents were monitored at 289nm. The retention times of Ciprofloxacin hydroch loride and Ornidazole were found to be 6.319mins and 2.944 mins respectively. The develope d method was validated in terms of linearity, accuracy, precision, LOD, LOQ as per ICH guidelines. Due to its simplicity, accuracy and high precision the proposed RP- HPLC m ethod can be used for the simultaneous estimation of both the drugs in its co mbined pharmaceutical dosage form.

  • To read the full article Visit
  • Open Access
This article was published in Journal of Advanced Pharmacy Education & Research and referenced in Pharmaceutical Analytical Chemistry

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version