alexa Development and Validation of Simultaneous HPLC method for Estimation of Telmisartan and Ramipril in Pharmaceutical Formulations
Chemical Engineering

Chemical Engineering

Journal of Chromatography & Separation Techniques

Author(s): Sunil Jawla, K Jeyalakshmi, T Krishnamurthy, Y Kumar

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A simple isocratic HPLC method has been developed and subsequently validated for simultaneous determination of Telmisartan and Ramipril in pharmaceutical dosage forms. The method employs an Inertsil ODS C18 column, 5 μ , 250mm x 4.60mm id with flow rate of 1.5 ml/min using PDA detection at 210nm. The separation was carried out using a mobile phase consisting of potassium di hydrogen phosphate buffer having pH 2.8 and Acetonitrile in the ratio of 60:40 respectively. The retention time for Telmisartan and Ramipril was found to be 5.7min and 10.8min respectively. A linear response was observed over the concentration range of 2.5-25.5ppm and 3.0-7.25ppm for the assay of Telmisartan and Ramipril respectively. The limit of detection and the limit of quantification for ramipril were found to be 0.75ppm and 2.5ppm respectively and for telmisartan were found to be 1.25ppm and 3.0ppm respectively. The results of analysis were validated statically and by recovery studies. Hence the proposed method was found to be accurate, precise, reproducible and specific and can be used for simultaneous analysis of these drugs in tablet formulation.

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This article was published in International Journal of PharmTech Research and referenced in Journal of Chromatography & Separation Techniques

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