alexa Development and Validation of Stability Indicating HPTLC method for Simultaneous Estimation of Paracetamol, Aceclofenac and Rabeprazole in Combined Tablet Dosage Formulation
Chemical Engineering

Chemical Engineering

Journal of Chromatography & Separation Techniques

Author(s): Mallikarjuna raoN

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A simple, sensitive, reliable and rapid HPTLC method has been developed for the determination of paracetamol, aceclofenac and rabeprazole in combined tablet dosage form. Determination was performed on aluminium backed silica gel 60F254 washed with methanol. The mobile phase used is ethyl acetate- methanol- glacial acetic acid (9: 1: 0.1). The spots were scanned at 275nm. The linearity of paracetamol, aceclofenac and rabeprazole was found to be 100-500µg/ml, 20-100µg/ml, 2-10µg/ml respectively. The method was validated for accuracy, precision, repeatability. The method was used for the determination of the compound in commercial pharmaceutical dosage forms.

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This article was published in International Journal of PharmTech Research and referenced in Journal of Chromatography & Separation Techniques

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