alexa Development of a melting tablet containing promethazine HCl against motion sickness.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Proteomics & Bioinformatics

Author(s): Haware RV, Chaudhari PD, Parakh SR, BauerBrandl A

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Abstract The purpose of this study was to design a 'Traveller Friendly Drug Delivery System' for PM-HCl. Conventional promethazine (PM-HCl) tablets are bitter, need to be taken 1 h before symptoms and water is also needed. Taste-masked granules were produced with Eudragit E100 by extrusion, and analyzed with FTIR, DSC, and XRD. Tablets formulated from granules by direct compression using Ac-Di-Sol, Polyplasdone-XL, Primojel and ion-exchanger Tulsion339 and evaluated for mass uniformity, friability, tensile strength, drug content uniformity, water absorption ratio, in-vitro and in-vivo disintegration time and in-vitro dissolution studies. The observed drug-polymer interactions and reduced crystallinity may be reasons for increased dissolution rates. The formulated tablets were disintegrated within 15 s. Tablets (25 mg PM-HCl) with Ac-Di-Sol (4\%) showed complete release within 1 min, while marketed conventional tablets (Phenergan; Rhone-Poulec) release 25\% during the same period. A preliminary stability studies for the prepared tablets carried at 30 +/- 2 degrees C/60 +/- 5\% RH, and 40 +/- 2 degrees C/75 +/- 5\%RH for 3 months showed no significant changes in the tablets quality at 30 +/- 2 degrees C/60 +/- 5\% RH. However, at 40 +/- 2 degrees C/75 +/- 5\%RH marked increase in in-vitro disintegration time, tensile strength and decrease in friability and water absorption ratio was found. The present studies indicate the abilities of Eudragit E 100 for taste masking and improving the dissolution profile of PM-HCl after complexation. In addition, by employing cost effective direct compression method, fast-dissolving tablets of 400 mg total weight with an acceptable quality could be prepared.
This article was published in AAPS PharmSciTech and referenced in Journal of Proteomics & Bioinformatics

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