alexa Development of a new biosensor for superoxide radicals.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Emregl E

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Abstract A superoxide dismutase (SOD) biosensor for determination of superoxide radicals has been developed by immobilization of superoxide dismutase within gelatin (G) on a Pt electrode surface. The properties of the biosensor have been investigated and optimum conditions-enzyme concentration, glutaraldehyde concentration, and pH-were determined. The response of the G-SOD biosensor was proportional to O2*- concentration and the detection limit was 0.01 mmol L(-1) at a signal-to-noise ratio of 3. The biosensor retained 89\% and 60\% of its sensitivity after use for three and four weeks, respectively. Immobilization of SOD on gelatin provides a biocompatible microenvironment around the enzyme and stabilizes the activity of the enzyme very efficiently. The superoxide dismutase biosensor was used to determine the antioxidant properties of acetylsalicylic acid-based drugs and the anti-radical activity of healthy and cancerous human brain tissues. This article was published in Anal Bioanal Chem and referenced in Pharmaceutica Analytica Acta

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