alexa Development of a validated RP-LC ESI-MS-MS method for separation, identification and determination of related substances of tamsulosin in bulk drugs and formulations.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Nageswara Rao R, Kumar Talluri MV, Narasa Raju A, Shinde DD, Ramanjaneyulu GS

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Abstract A reversed-phase high performance liquid chromatographic (RP-HPLC) method for evaluation of purity of tamsulosin in bulk drugs and pharmaceuticals was developed. The separation was accomplished on an Inertsil C(18) column using 10 mM ammonium acetate: acetonitrile as a mobile phase in a gradient elution mode. A photodiode array detector set at 280 nm was used for detection. The impurities were identified by ESI-MS-MS. The detection limits were 0.06-0.11 microg/ml. The method was validated with respect to accuracy, precision, linearity, ruggedness and limits of detection and quantification. It finds application not only for monitoring the reactions during the process development but also on quality assurance of tamsulosin. This article was published in J Pharm Biomed Anal and referenced in Pharmaceutica Analytica Acta

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