alexa Development of an inactivated candidate vaccine against Chandipura virus (Rhabdoviridae: Vesiculovirus).
Immunology

Immunology

Journal of Clinical & Cellular Immunology

Author(s): Jadi RS, Sudeep AB, Barde PV, Arankalle VA, Mishra AC

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Abstract A Vero cell based vaccine candidate against Chandipura (CHP) virus (Rhabdoviridae: Vesiculovirus), was developed and evaluated for immunogenicity in mice. Virus was purified by ultracentrifugation on 30\% glycerol cushion followed by differential centrifugation on 10-60\% sucrose gradient and inactivated with β-propio lactone at a concentration of 1:3500. The inactivated product was blended with aluminium phosphate (3\%) and immunized 4-week-old Swiss albino mice. Neutralizing antibodies in the range of 1:10 to 160 and 1:80 to 1:320 was detected with 85\% and 100\% sero-conversion after 2nd and 3rd dose, respectively. All the immunized mice with antibody titer above 1:20 survived live virus challenge. The vaccine candidate has potential to be an efficient vaccine against CHP virus. Copyright © 2011 Elsevier Ltd. All rights reserved. This article was published in Vaccine and referenced in Journal of Clinical & Cellular Immunology

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