alexa Development of analytical method for determination of quetiapine fumarate in bulk & tablet dosage form
Chemical Engineering

Chemical Engineering

Journal of Chromatography & Separation Techniques

Author(s): Pramod L Ingale, Sampada D Dalvi, Sachin V Gudi, Laxmileena D Patil, Deepali D Jadav

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A new, simple, specific, sensitive, rapid, accurate and precise RP-HPLC method was developed for the e stimation of quetiapine fumarate in bulk and pharmaceutical form ulations. Quetiapine fumarate was chromatographed o n Microsorb-MV 100-5 C-18 (250 x 4.6mm, 5 μm) column using UV detector. The mobile phase consisting acetonitrile and phosphate buffer (pH 3) in the rat io of 50:50 (v/v) at a flow rate of 1.0 ml/min with detection at 292 nm. The method was validated according to the ICH g uidelines with respect to specificity, linearity, a ccuracy, precision and robustness.

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This article was published in Der Pharma Chemica and referenced in Journal of Chromatography & Separation Techniques

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