alexa Development of membrane selective electrode for determination of the antipsychotic sulpiride in pharmaceuticals and urine.
Chemical Engineering

Chemical Engineering

Journal of Analytical & Bioanalytical Techniques

Author(s): Garca MS, Ortuo JA, Albero MI, Abuherba MS

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Abstract The construction and electrochemical response characteristics of a poly(vinyl chloride) (PVC) membrane selective electrode for the determination of sulpiride (SPD) are described. The sensing membrane comprised an ion-exchanger formed between the protonated drug and tetraphenylborate (TPB(-)) in a plasticized PVC matrix. The influence of membrane composition on the electrode response was studied. The electrode showed a fast, stable and Nernstian response over a sulpiride concentration range (1 × 10(-4) - 1 × 10(-2) M) with a mean slope of 58.4 ± 0.9 mV dec(-1) of concentration, a mean detection limit of 4.2 × 10(-5) ± 1.2 × 10(-5) M, a wide working pH range (2 - 8) and a fast response time (< 15 s). The electrode showed good selectivity towards sulpiride with respect to some inorganic and organic compounds. When the electrode was applied to the determination of sulpiride in pharmaceuticals and human urine, a high percentage of recovery was attained with no need for sample pretreatment procedures because of the lack of interfering matrix effects.
This article was published in Sensors (Basel) and referenced in Journal of Analytical & Bioanalytical Techniques

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