alexa Development of the mammalian lymphatic vasculature.
Immunology

Immunology

Journal of Clinical & Cellular Immunology

Author(s): Yang Y, Oliver G

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Abstract The two vascular systems of our body are the blood and lymphatic vasculature. Our understanding of the cellular and molecular processes controlling the development of the lymphatic vasculature has progressed significantly in the last decade. In mammals, this is a stepwise process that starts in the embryonic veins, where lymphatic EC (LEC) progenitors are initially specified. The differentiation and maturation of these progenitors continues as they bud from the veins to produce scattered primitive lymph sacs, from which most of the lymphatic vasculature is derived. Here, we summarize our current understanding of the key steps leading to the formation of a functional lymphatic vasculature.
This article was published in J Clin Invest and referenced in Journal of Clinical & Cellular Immunology

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