Author(s): Moritz KM, Lim GB, Wintour EM, Moritz KM, Lim GB, Wintour EM, Moritz KM, Lim GB, Wintour EM, Moritz KM, Lim GB, Wintour EM
Abstract Share this page
Abstract It is well established that erythropoiesis occurs first in the yolk sac, then in the liver, subsequently moving to the bone marrow and, in rodents, the spleen during development. The origin of the erythropoietic precursors and some factors suggested to be important for the changing location of erythropoiesis are discussed in this review. Until recently, the major site of erythropoietin (Epo) production in the fetus was thought to be the liver, but studies have shown now that the Epo gene is expressed strongly in the fetal kidney, even in the temporary mesonephros. The metanephric Epo mRNA is upregulated by anemia, downregulated by glucocorticoids, and contributes substantially to circulating hormone levels in hemorrhaged ovine fetuses. Other sites of Epo and Epo receptor production, likely to have important actions during development, are the placenta and the brain.
This article was published in Am J Physiol
and referenced in Journal of Integrative Oncology