Author(s): Richard JL, Lavigne JP, Sotto A
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Abstract BACKGROUND: Infection of foot ulcers is a common, often severe and costly complication in diabetes. Many factors linked to the host, mainly immune defects, neuropathy and arteriopathy, as well as bacteria-related factors, interact in a complex way and account for the susceptibility of diabetic individuals to foot infections, the severity of such infections and difficulty to treat them. METHODS: This article reviews these factors, in the light of data from the literature and from our own results. RESULTS: DFIs are not as simple as previously suggested, and new concepts must be considered, especially the virulence potential of isolates and bacterial communications through biofilms. CONCLUSION: The development of new tools from molecular biology is a critical step to better understand and manage these infections. Copyright © 2012 John Wiley & Sons, Ltd.
This article was published in Diabetes Metab Res Rev
and referenced in Journal of Ecosystem & Ecography