alexa Diabetes and Microvascular Physio-Pathology: Role of Epidermal Growth Factor Receptor Tyrosine Kinase
Diabetes & Endocrinology

Diabetes & Endocrinology

Journal of Diabetes & Metabolism

Author(s): Khalid Matrougui

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Type 2 diabetes is responsible for the increased prevalence of ischemic heart disease, generally related to coronary artery disease, which is associated with increased morbidity and death in diabetic patients. Epidermal growth factor receptor (EGFR) tyrosine kinase, one of the many factors involved in cell growth and migration has been shown to be key element in the development of microvessel myogenic tone. In a recent study, we have shown that microvascular dysfunction in type 2 diabetes is dependent on the exacerbation of the EGFR tyrosine kinase phosphorylation. Thus, further elucidation of this EGFR transactivation and down stream signaling will offer a new direction for the investigation of the mechanism of microvascular dysfunction responsible for heart disease that occurs in type 2 diabetes. In this review, we discuss the link between the EGFR transactivation and microvascular dysfunction that occurs in type 2 diabetes.

This article was published in Diabetes Metab Res Rev and referenced in Journal of Diabetes & Metabolism

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