Author(s): Lipscombe LL, Goodwin PJ, Zinman B, McLaughlin JR, Hux JE
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Abstract PURPOSE: Evidence suggests that women with type 2 diabetes may be at increased risk of breast cancer, possibly due to chronic exposure to insulin resistance and/or hyperinsulinemia. The purpose of this study was to compare the incidence of breast cancer in postmenopausal women with and without diabetes. METHODS: Using population-based validated health databases from Ontario, Canada, this retrospective cohort study compared breast cancer incidence between women, aged 55-79 years, with newly diagnosed diabetes (n=73,796) to women without diabetes (n=391,714). RESULTS: Women with diabetes were slightly older, were more likely to reside in a lower income neighborhood, had greater comorbidity, and had more annual physician visits than women without diabetes. After 2.2 million person-years of follow-up from 1994 to 2002, breast cancer incidence was 2.97/1000 person-years in the diabetes group and 2.75/1000 person-years in the non-diabetes group. After adjustment for age and income, there was a significant increase in breast cancer among women with diabetes (hazard ratio, HR, 1.08, 95\% confidence interval, CI, 1.01-1.16, p=0.021). CONCLUSION: This study found a small but significant increase in incident breast cancer in a predominantly postmenopausal population of women with diabetes, when compared to women without diabetes. These results support the possibility that insulin resistance or some other aspect of type 2 diabetes may promote breast cancer, and may further direct treatment and prevention strategies.
This article was published in Breast Cancer Res Treat
and referenced in Advances in Pharmacoepidemiology and Drug Safety