Author(s): Subramaniam M, Chong SA, Pek E, Subramaniam M, Chong SA, Pek E
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Abstract OBJECTIVES: This study aimed to establish the prevalence of diabetes mellitus (DM) and impaired glucose tolerance in patients with schizophrenia and to elucidate some of the factors associated with hyperglycemia. METHODS: We studied a sample of 194 patients with schizophrenia. We determined fasting blood glucose and insulin levels at the start of the testing period; patients were given an oral glucose tolerance test after an overnight fast. RESULTS: The overall prevalence of diabetes and impaired glucose tolerance in these patients was 16.0\% and 30.9\%, respectively. These rates were higher than those reported in the general population. Patients with disordered glucose homeostasis were significantly older (P = 0.005, Kruskal-Wallis test). There was no significant effect of sex or ethnicity on diabetes. CONCLUSIONS: Our findings suggest that patients with schizophrenia are more vulnerable to developing DM. We caution clinicians to be mindful of the increased risk and to be vigilant for such a development.
This article was published in Can J Psychiatry
and referenced in Journal of Psychiatry