Author(s): Jehenson P, Duboc D, Bloch G, Fardeau M, Syrota A
Abstract Share this page
Abstract Natural abundance 13C NMR (nuclear magnetic resonance) spectroscopy was used to distinguish patients suffering from muscle glycogenosis type V (McArdle's disease) from normal subjects by measuring their muscle glycogen content at rest. Proton-decoupled 13C spectra were obtained in 10-15 min from calf muscles at rest. The ratio of the glycogen/creatine signal areas was 12.9 +/- 1.7 in four McArdle's disease patients and 2.0 +/- 0.7 in seven normal subjects. This technique thus allows the non-invasive diagnosis of muscle glycogenosis.
This article was published in Neuromuscul Disord
and referenced in International Journal of Physical Medicine & Rehabilitation