alexa Diagnostic Criteria for Multiple Sclerosis: 2010 Revisions to the McDonald Criteria


Journal of Pediatric Neurological Disorders

Author(s): Chris H Polman, Stephen C Reingold, Brenda Banwell, Michel Clanet, Jeffrey A Cohen

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Diagnostic criteria for multiple sclerosis (MS) include clinical and paraclinical laboratory assessments1,2 emphasizing the need to demonstrate dissemination of lesions in space (DIS) and time (DIT) and to exclude alternative diagnoses. Although the diagnosis can be made on clinical grounds alone, magnetic resonance imaging (MRI) of the central nervous system (CNS) can support, supplement, or even replace some clinical criteria,3–9 as most recently emphasized by the so-called McDonald Criteria of the International Panel on Diagnosis of MS.8,9 The McDonald Criteria have resulted in earlier diagnosis of MS with a high degree of both specificity and sensitivity,10–13 allowing for better counseling of patients and earlier treatment. Since the revision of the McDonald Criteria in 2005, new data and consensus have pointed to the need for their simplification to improve their comprehension and utility and for evaluating their appropriateness in populations that differ from the largely Western Caucasian adult populations from which the Criteria were derived. In May 2010 in Dublin, Ireland, the International Panel on Diagnosis of MS (the Panel) met for a third time to examine requirements for demonstrating DIS and DIT and to focus on application of the McDonald Criteria in pediatric, Asian, and Latin American populations.

This article was published in Ann Neurol and referenced in Journal of Pediatric Neurological Disorders

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