Author(s): Damjanovska L, Thabet MM, Levarth EW, StoekenRijsbergen G, van der Voort EI,
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Abstract OBJECTIVES: To evaluates the diagnostic performance of the anti-CCP2, anti-CCP3 and anti-mutated citrullinated vimentin (anti-MCV) tests in differentiating rheumatoid arthritis (RA) from other forms of arthritis in a clinical setting of early arthritis. METHODS: In 917 patients with recent-onset arthritis (566 RA, 351 other diseases) and in 99 healthy controls the anti-MCV, anti-CCP2 and anti- CCP3.1 tests were performed and the test characteristics compared. RESULTS: Comparison of the tests for differentiating RA from other causes of arthritis showed a lower specificity for anti-MCV (82.9\%) than for anti-CCP2 (93.4\%) and anti-CCP3.1 (90.0\%). Similarly, the positive likelihood ratio for anti-MCV was also lower (3.6, compared with 8.7, 5.8 for anti-CCP2 and anti-CCP3.1). The anti-MCV test had a higher sensitivity (62\% vs 56.9\% and 58.1\%, respectively). In psoriatic arthritis, spondyloarthropathy and other arthritis anti-MCV antibodies had a prevalence of 15.2\%, 13.9\% and 19.4\%. CONCLUSION: The diagnostic performance of the anti-MCV test in the differential diagnosis of early arthritis is lower than that of the anti-CCP tests.
This article was published in Ann Rheum Dis
and referenced in Journal of Clinical & Cellular Immunology