Author(s): Al Moudi M, Sun Z, Lenzo N
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Abstract PURPOSE: The purpose of the study was to investigate the diagnostic value of SPECT, PET and PET/CT in the diagnosis of coronary artery disease, based on a systematic review. MATERIAL AND METHODS: A search of PubMed/Medline and Sciencedirect databases in the English-language literature published over the last 24 years was performed. Only studies with at least 10 patients comparing SPECT, PET or combined PET/CT with invasive coronary angiography in the diagnosis of coronary artery disease (50\% stenosis) were included for analysis. Sensitivities and specificities estimates pooled across studies were analysed using a Chi-square test. RESULTS: Twenty-five studies met the selection criteria and were included for the analysis. Ten studies were performed with SPECT alone; while another six studies were performed with PET alone. Five studies were carried out with both PET and SPECT modalities, and the remaining four studies were investigated with integrated PET-CT. The mean value of sensitivity, specificity and accuracy of these imaging modalities for the diagnosis of coronary artery disease was 82\% (95\%CI: 76 to 88), 76\% (95\%CI: 70 to 82) and 83\% (95\%CI: 77 to 89) for SPECT; 91\% (95\%CI: 85 to 97), 89\% (95\%CI: 83 to 95) and 89\% (95\%CI: 83 to 95) for PET; and 85\% (95\%CI: 79 to 90), 83\% (95\%CI: 77 to 89) and 88\% (95\%CI: 82 to 94) for PET/CT, respectively. The diagnostic accuracy of these imaging modalities was dependent on the radiotracers used in these studies, with ammonia resulting in the highest diagnostic value. CONCLUSION: Our review shows that PET has high diagnostic value for diagnosing coronary artery disease, and this indicates that it is a valuable technique for both detection and prediction of coronary artery disease.
This article was published in Biomed Imaging Interv J
and referenced in Journal of Clinical & Experimental Cardiology