alexa Diboronic acids as fluorescent probes for cells expressing sialyl Lewis X.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Glycomics & Lipidomics

Author(s): Yang W, Gao S, Gao X, Karnati VV, Ni W,

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Abstract A series of fluorescent diboronic acids was synthesized in nine steps as potential sensors for sialyl Lewis X (sLex). The fluorescent binding studies of these sensors with sLex were carried out in a mixed aqueous solution. Compound 7e was found to show the strongest fluorescence enhancement upon binding with sLex. Using cell cultures, 7e was shown to label sLex-expressing HEPG2 cells at 1 microM, while non-sLex-expressing cells were not labeled.
This article was published in Bioorg Med Chem Lett and referenced in Journal of Glycomics & Lipidomics

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