alexa Dietary elimination therapy is an effective option for adults with eosinophilic esophagitis.


Journal of Hepatology and Gastrointestinal disorders

Author(s): Wolf WA, Jerath MR, Sperry SL, Shaheen NJ, Dellon ES

Abstract Share this page

Abstract BACKGROUND & AIMS: Eosinophilic esophagitis (EoE) is an immune-mediated disorder. Food elimination is an established treatment for children, but data in adults are limited. We aimed to determine the response of adults with EoE to dietary therapy. METHODS: This was a retrospective cohort study using the University of North Carolina EoE database from 2006 to 2012. Subjects were age 18 and older, had EoE by consensus guidelines, and had undergone dietary therapy either with a targeted elimination diet or a 6-food elimination diet (SFED). Outcomes were symptomatic, endoscopic, and histologic improvement. Demographic, endoscopic, symptomatic, and laboratory predictors of response to dietary therapy were assessed. RESULTS: Of 31 adults who underwent dietary therapy (mean age, 36 y; 48\% male; 90\% white; mean baseline eosinophil count, 78 eos/hpf), 22 had a targeted elimination diet and 9 had SFED. Symptoms improved in 71\% (68\% in targeted, 78\% in SFED), and endoscopic appearance improved in 54\% (53\% in targeted, 56\% in SFED). After dietary therapy, the mean eosinophil count decreased to 43 eos/hpf (P = .009). Eleven subjects (39\%) responded with fewer than 15 eos/hpf (32\% in targeted and 56\% in SFED; P = .41). No clinical, endoscopic, or histologic factors predicted response to dietary therapy. Of the 11 responders, 9 underwent food re-introduction to identify trigger(s), and 4 (44\%) reacted to dairy, 4 (44\%) reacted to eggs, 2 (22\%) reacted to wheat, 1 (11\%) reacted to shellfish, 1 (11\%) reacted to legumes, and 1 (11\%) reacted to nuts. CONCLUSIONS: Dietary elimination is a successful treatment modality for adults with EoE. Further research should emphasize which factors can predict effective dietary therapy. Copyright © 2014 AGA Institute. Published by Elsevier Inc. All rights reserved.
This article was published in Clin Gastroenterol Hepatol and referenced in Journal of Hepatology and Gastrointestinal disorders

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version