Author(s): Duteil L, CardotLeccia N, QueilleRoussel C, Maubert Y, Harmelin Y, , Duteil L, CardotLeccia N, QueilleRoussel C, Maubert Y, Harmelin Y,
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Abstract The visible light spectrum is wide, and it can be hypothesized that all the wavelengths between 400-700 nm do not induce the same photobiological effects on pigmentation. We assessed the potential pro-pigmenting effects of two single wavelengths located at both extremities of the visible spectrum: the blue/violet line (λ = 415 nm) and the red line (λ = 630 nm). We made colorimetric, clinical, and histological assessments with increasing doses of those lights on healthy volunteers. Then, we compared these irradiations to non-exposed and UVB-exposed skin. Colorimetric and clinical assessments showed a clear dose effect with the 415-nm irradiation, in both skin type III and IV subjects, whereas the 630 nm did not induce hyperpigmentation. When compared to UVB irradiation, the blue-violet light induced a significantly more pronounced hyperpigmentation that lasted up to 3 months. Histological examination showed a significant increase of keratinocyte necrosis and p53 with UVB, as compared to 415- and 630-nm exposures. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
This article was published in Pigment Cell Melanoma Res
and referenced in Dermatology and Dermatologic Diseases