Author(s): Jimnez de Bags MP, LoiselMeyer S, Liautard JP, JubierMaurin V
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Abstract The survival of Brucella suis mutant strains in mice demonstrated different roles of the two high-oxygen-affinity terminal oxidases. The cbb3-type cytochrome c oxidase was essential for chronic infection in oxygen-deficient organs. Lack of the cytochrome bd ubiquinol oxidase led to hypervirulence of bacteria, which could rely on nitrite accumulation inhibiting the inducible nitric oxide synthase of the host.
This article was published in Infect Immun
and referenced in Journal of Bioterrorism & Biodefense