alexa Differential Association of Products of Alternative Transcripts of the Candidate Tumor Suppressor ING1 with the mSin3 HDAC1 Transcriptional Corepressor Complex
Genetics

Genetics

Journal of Aging Science

Author(s): Dorota Skowyra, Marija Zeremski, Nickolay Neznanov, Muyang Li, Yongmun Choi

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The candidate tumor suppressor ING1was identified in a genetic screen aimed at isolation of human genes whose expression is suppressed in cancer cells. It may function as a negative growth regulator in the p53 signal transduction pathway. However, its molecular mechanism is not clear. The ING1locus encodes alternative transcripts of p47ING1a, p33ING1b, and p24ING1c. Here we report differential association of protein products of ING1 with the mSin3 transcriptional corepressor complex. p33ING1bassociates with Sin3, SAP30, HDAC1, RbAp48, and other proteins, to form large protein complexes, whereas p24ING1c does not. The ING1 immune complexes are active in deacetylating core histones in vitro, and p33ING1b is functionally associated with HDAC1-mediated transcriptional repression in transfected cells. Our data provide basis for a p33ING1b-specific molecular mechanism for the function of the ING1 locus.

This article was published in The Journal of Biological Chemistry and referenced in Journal of Aging Science

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