alexa Differential compartmentalization of brain ascorbate and glutathione between neurons and glia.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Stem Cell Research & Therapy

Author(s): Rice ME, RussoMenna I

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Abstract Compartmentalization of brain ascorbate and glutathione between neurons and glia has been a source of controversy. To address this question, we determined the ascorbate and glutathione contents of brain tissue with defined, but varying, densities of neurons and glia. In developing rat cortex and hippocampus, glutathione content rose during gliogenesis, while ascorbate fell. By contrast, ascorbate, but not glutathione, increased markedly during granule cell proliferation and maturation in the developing cerebellum. Similarly, in tissue from adult cerebral cortex of species with distinct neuron densities, ascorbate content increased linearly with increasing neuron density in the order: human This article was published in Neuroscience and referenced in Journal of Stem Cell Research & Therapy

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