alexa Differential effects of grape seed extract against human colorectal cancer cell lines: the intricate role of death receptors and mitochondria.
Oncology

Oncology

Journal of Carcinogenesis & Mutagenesis

Author(s): Derry M, Raina K, Agarwal R, Agarwal C

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Abstract Failure of anti-cancer therapy in colorectal cancer (CRC) cells involves resistance to death mechanisms. We investigated grape seed extract (GSE) ability to target CRC cells and delineated the mechanisms involved in GSE-induced CRC cell death. GSE selectively induced apoptotic death in human CRC cells; efficacy increased as the metastatic potential of the cancer cells increased. Oxidative stress, loss of mitochondrial membrane potential, modulation of pro- and anti-apoptotic proteins, and involvement of both caspase-dependent/independent apoptotic pathways contributed to GSE-induced CRC cell death. GSE intervention may serve as a multi-targeted CRC therapeutic capable of inducing selective cancer cell death. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
This article was published in Cancer Lett and referenced in Journal of Carcinogenesis & Mutagenesis

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