alexa Differential expression of PDZ domain-containing proteins in human diseases - challenging topics and novel issues.
Reproductive Medicine

Reproductive Medicine

Gynecology & Obstetrics

Author(s): Facciuto F, Cavatorta AL, Valdano MB, Marziali F, Gardiol D

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The general features of the PDZ domain structure and functions have been extensively studied during the last decade. PDZ domains are generally present in proteins that are involved in multiple interactions to assemble functional protein complexes that control key cellular processes. One of the best characterized functions of PDZ domain-containing proteins is control of epithelial cell polarity and cell-cell contacts. In the present review, we summarize the current knowledge on regulation of expression of certain PDZ polarity proteins localized at the intercellular junctions. In addition, we provide a critical overview of recent findings regarding the role of these proteins during development of human diseases. Complete understanding of these issues is valuable for the design of novel therapeutic intervention for common pathologies, such as cancer.

This article was published in FEBS J. and referenced in Gynecology & Obstetrics

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