alexa Differential mobilization of white adipose tissue fatty acids according to chain length, unsaturation, and positional isomerism.
Microbiology

Microbiology

Journal of Antivirals & Antiretrovirals

Author(s): Raclot T, Groscolas R

Abstract Share this page

Abstract The present study aims at determining whether, and how, the molecular structure of fatty acids influences their mobilization from fat cells. The in vitro mobilization of 52 fatty acids ranging in chain length from 12 to 24 carbon atoms, in unsaturation from 0 to 6 double bonds, and including 23 pairs of positional isomers was examined. Fat cells were isolated from adipose tissue of rats fed a fish-oil diet and treated with norepinephrine to stimulate lipolysis. Fatty acid composition of free fatty acids (FFA) released from these cells was compared to that of the triacylglycerols (TAG) from which they originated. The percentage weight of most fatty acids, and especially that of very long-chain fatty acids, was significantly different between FFA and TAG. The percentage of 20:5n-3 (eicosapentaenoic acid) and of 20:4n-6 (arachidonic acid) was 2.7 and 1.7 times higher in FFA than in TAG, respectively, whereas that of 20:1(n-11, 9 or 7), 22:1(n-11, 9 or 7) and 24:1n-9 was 1.7-2, 2.4, and 3.5 times lower, respectively. The relative mobilization (\% in FFA/\% in TAG) of the least readily mobilized fatty acid (24:1n-9) was 15-fold lower than that of the most readily mobilized (18:5n-3). For a given chain length, the relative mobilization increased exponentially with unsaturation, e.g., increasing from 0.45 to 2.7 in C 20 fatty acids when the number of double bonds increased from 0 to 5. Amongst the fatty acids with 18 to 22 carbon atoms, the shorter the chain was, the more steeply relative mobilization increased with unsaturation. On the other hand, for a given unsaturation the relative mobilization decreased with increasing chain length, e.g., decreasing from 1.15 to 0.3 in monoenes when the chain length increased from C 14 to C 24. A two-carbon-atom shortening of the chain length was on average equivalent to inserting one double bond for increasing the relative mobilization, i.e., by about 40\%. The relative mobilization was also affected by the position of the double bond(s); increasing on average by 10\% when there was a two-carbon-atom displacement towards the methyl end of the chain. These results demonstrate that under conditions of stimulated lipolysis individual fatty acids are more readily mobilized from fat cells when they are short and unsaturated, and when their double bonds are closer to the methyl end of the chain.(ABSTRACT TRUNCATED AT 400 WORDS)
This article was published in J Lipid Res and referenced in Journal of Antivirals & Antiretrovirals

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords