alexa Differential pattern of brain-specific CSF proteins tau and amyloid-β in Parkinsonian syndromes.


Journal of Alzheimers Disease & Parkinsonism

Author(s): Sssmuth SD, Uttner I, Landwehrmeyer B, Pinkhardt EH, Brettschneider J,

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Abstract To evaluate cerebrospinal fluid (CSF) proteins reflecting processes of neurodegeneration and glial activation in progressive supranuclear palsy (PSP; Richardson's syndrome, n = 20; PSP-Parkinsonism, n = 7) and multiple system atrophy (MSA, n = 25), we analyzed tau, phosphorylated tau, amyloid-beta(1-42) (Abeta1-42), Abeta1-40, glial fibrillary acidic protein (GFAP), and CSF routine variables. Individuals with PSP-Parkinsonism and MSA had elevated tau levels when compared with Richardson's syndrome, Parkinson's disease (PD), and age-matched controls (P
  • DOI: 10.1002/mds.22895
  • This article was published in Mov Disord and referenced in Journal of Alzheimers Disease & Parkinsonism

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