Author(s): Benda P, Lightbody J, Sato G, Levine L, Sweet W
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Abstract Rat glial tumors, induced by injections of N-nitrosomethylurea, were plated and propagated in culture. Among a few cell strains obtained, one clone contains S-100 protein, which is unique to brain in vertebrates. Stationary-phase cultures contain approximately ten times more S-100 protein per cell than exponentially growing cells. When injected into newborn rats, cells producing S-100 grew as a glial tumor, which contained S-100 protein.
This article was published in Science
and referenced in Journal of Steroids & Hormonal Science