Author(s): Jang SH, Cho SH, Kim YH, Han BS, Byun WM,
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Abstract PURPOSE: This study examined whether the degree of impairment of diffusion anisotrophy in the early stages of a stroke can predict the motor function outcome. METHODS: Thirty-one hemiplegic stroke patients were enrolled to this study. Diffusion anisotropy was measured by determining fractional anisotropy (FA) in the two ROIs (region of interests) at corona radiata (CR) and in the posterior limb of internal capsule (IC) during the early stages of stoke (average 7.9 days after stroke onset) and compared with motor outcome of the affected hand 3 months after stroke onset. RESULTS: Both ROIs (CR or IC) and lesion types (hemorrhage or infarction) did not have significant effect on the SBFA (symmetry of bilateral FA) and dMRC (medical research council score improvement), either. Patients with greater initial MRC score had significantly greater SBFA and dMRC. The regression equation between the dMRC (Y axis) and the SBFA (X axis) was semi-linear and significant (P < 0.05); for CR group, Y = 3.296 - 0.1192X + 0.0015X2; for IC group, Y = 2.342 - 0.0533X +0.0007(2). The regression lines had 'threshold points' where a minute SBFA change would make a steep increase in dMRC. CONCLUSION: The degree of impairment in diffusion anisotropy during the early stages of stroke appears to have the potential to predict motor outcome.
This article was published in Restor Neurol Neurosci
and referenced in Journal of Cell Science & Therapy