alexa Diffusion on membrane tubes: a highly discriminatory test of the Saffman-Delbruck theory.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Daniels DR, Turner MS

Abstract Share this page

Abstract The efficient transport of membrane proteins is vital in maintaining life. In this work, we investigate the transport of such membrane proteins along long thin membrane tubes or tethers. We calculate the diffusion constant to leading order in the low Reynolds number regime to be D = (4 pi eta)-1 log(r/a), with r and a being the tube and protein radii, respectively, and eta being the membrane viscosity. Thus we propose an exact limiting form for the controversial logarithmic correction, such as originally introduced by Saffman and Delbruck, that involves the tube radius rather than some "frame size". Our work suggests a test of this logarithmic correction could be achieved by measuring diffusion on membrane tubes, exploiting the fact that the equilibrium tube radius can be controlled by the membrane tension and varied over several orders of magnitude. We analyze the time taken for a protein to transit a membrane tube between cells and find that this can vary by an order of magnitude over physiological tensions. This is a strong effect in biological terms and suggests a possible regulatory coupling between membrane tension and signaling. This article was published in Langmuir and referenced in Pharmaceutica Analytica Acta

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version