Author(s): Ratnapalan S, Griffiths K, Costei AM, Benson L, Koren G
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Abstract Digoxin is often coadministered with carvedilol in children with severe ventricular failure. In eight children (age 2 weeks to 8 years), the oral clearance of digoxin decreased by half with carvedilol, and two of them had digoxin toxicity. Carvedilol increases serum concentrations of digoxin in children, and its dose may need to be reduced to avoid toxicity.
This article was published in J Pediatr
and referenced in Journal of Proteomics & Bioinformatics