Author(s): Endo A, Hasumi K, Nakamura T, Kunishima M, Masuda M
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Abstract Dihydromonacolin L and monacolin X those are structurally related to monacolin K, a potent inhibitor of cholesterol biosynthesis, were isolated from cultures of a mutant of Monascus ruber. The structures of these two metabolites were determined by a combination of physical techniques. Data for dihydromonacolin L and monacolin X as inhibitors of hydroxymethylglutaryl-CoA reductase and sterol biosynthesis in vitro are also given.
This article was published in J Antibiot (Tokyo)
and referenced in Journal of Addiction Research & Therapy