alexa Direct comparison of histology of microbleeds with postmortem MR images: a case report.


Journal of Neurology & Neurophysiology

Author(s): Tatsumi S, Shinohara M, Yamamoto T

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Abstract BACKGROUND: Although the clinical significance of so-called microbleeds (MBs) in gradient-echo MR images (GRE-MRI) has been extensively researched, the histopathological evaluation is notably insufficient. METHODS: Postmortem GRE-MRI was obtained of water-immersed formalin-fixed tissue blocks from a 97-year-old hypertensive woman with 9 antemortem MBs. Histologic slides were compared with those of MRI. RESULTS: Microscopic examination revealed clusters of hemosiderin-laden macrophages in 8 MBs and arteriolar pseudocalcification in 1 MB in the left pallidum. Hypertensive microangiopathies were found in 5 lesions. The sizes of the lesions with hemosiderin deposits were roughly comparable with the MBs of GRE-MRI. CONCLUSIONS: All of the MBs but for 1 exception were proved to be hemosiderin deposits and frequently associated with hypertensive microangiopathy. (c) 2008 S. Karger AG, Basel. This article was published in Cerebrovasc Dis and referenced in Journal of Neurology & Neurophysiology

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