alexa Direct tissue analysis using matrix-assisted laser desorption ionization mass spectrometry: practical aspects of sample preparation.
Chemical Engineering

Chemical Engineering

Mass Spectrometry & Purification Techniques

Author(s): Schwartz SA, Reyzer ML, Caprioli RM

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Abstract Practical guidelines for the preparation of tissue sections for direct analysis by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry are presented. Techniques for proper sample handling including tissue storage, sectioning and mounting are described. Emphasis is placed on optimizing matrix parameters such as the type of matrix molecule used, matrix concentration, and solvent composition. Several different techniques for matrix application are illustrated. Optimal instrument parameters and the necessity for advanced data analysis approaches with regards to direct tissue analysis are also discussed. Copyright 2003 John Wiley & Sons, Ltd. This article was published in J Mass Spectrom and referenced in Mass Spectrometry & Purification Techniques

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