alexa Directing transition from innate to acquired immunity: defining a role for IL-6.


Journal of Nutrition & Food Sciences

Author(s): Jones SA

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Abstract Appropriate control of leukocyte recruitment and activation is a fundamental requirement for competent host defense and resolving inflammation. A pivotal event that defines the successful outcome of any inflammatory event is the transition from innate to acquired immunity. In IL-6 deficiency, this process appears defective, and a series of in vivo studies have documented important roles for IL-6 in both the resolution of innate immunity and the development of acquired immune responses. Within this review, particular attention will be given to the regulatory properties of the soluble IL-6 receptor and how its activity may affect chronic disease progression.
This article was published in J Immunol and referenced in Journal of Nutrition & Food Sciences

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