Author(s): Salter MM, Kobayashi J, Shimizu Y, Kobayashi S
Abstract Share this page
Abstract [reaction: see text] The first example of the Lewis acid-catalyzed three-component direct-type Mannich reaction of simple aromatic and enolizable aliphatic aldehydes, secondary amines, and glycine derivatives is described. The procedure is highly atom economical and can be performed in a simple one-pot operation under mild conditions to afford a wide variety of synthetically important anti-alpha,beta-diamino ester derivatives in high yields with high diastereoselectivities.
This article was published in Org Lett
and referenced in Medicinal Chemistry