alexa Direct-type catalytic three-component mannich reactions leading to an efficient synthesis of alpha,beta-diamino acid derivatives.
Chemistry

Chemistry

Medicinal Chemistry

Author(s): Salter MM, Kobayashi J, Shimizu Y, Kobayashi S

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Abstract [reaction: see text] The first example of the Lewis acid-catalyzed three-component direct-type Mannich reaction of simple aromatic and enolizable aliphatic aldehydes, secondary amines, and glycine derivatives is described. The procedure is highly atom economical and can be performed in a simple one-pot operation under mild conditions to afford a wide variety of synthetically important anti-alpha,beta-diamino ester derivatives in high yields with high diastereoselectivities. This article was published in Org Lett and referenced in Medicinal Chemistry

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