alexa Discovery of a novel class of PPARdelta partial agonists.


Medicinal chemistry

Author(s): Shearer BG, Patel HS, Billin AN, Way JM, Winegar DA,

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Abstract Anthranilic acid GW9371 was identified as a novel class of PPARdelta partial agonist through high-throughput screening. The design and synthesis of SAR analogues is described. GSK1115 and GSK7227 show potent partial agonism of the PPARdelta target genes CPT1a and PDK4 in skeletal muscle cells. This article was published in Bioorg Med Chem Lett and referenced in Medicinal chemistry

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