Author(s): Jones MS, Lukashov VV, Ganac RD, Schnurr DP
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Abstract Fever of unknown origin (FUO) is a serious problem in the United States. An unidentified agent was cultured from the stool of an infant who presented with FUO. This virus showed growth in HFDK cells and suckling mice. Using DNase sequence-independent single-primer amplification, we identified several nucleotide sequences with a high homology to Theiler's murine encephalomyelitis virus. Nearly full-length viral genome sequencing and phylogenetic analysis demonstrate that this virus is a member of the Cardiovirus genus of the Picornaviridae family.
This article was published in J Clin Microbiol
and referenced in Journal of Biomedical Systems & Emerging Technologies